Renal Pathology In the Department of Pathology
 Polyoma virus associated interstitial nephritis
 Polyoma virus associated interstitial nephritis

Biopsy Services, Specimen Delivery, Requirements and Requisitions

We provide the full range of diagnostic services for adults and children with kidney disease including light microscopy, immunofluorescence, immunohistochemistry and electron microscopy.

Our Clinical laboratory offers numerous tests that may be useful in establishing a diagnosis and following the course of the patient’s disease during and after therapeutic intervention.

Preliminary light microscopic and immunofluorescence and/or immunohistochemical results are called or faxed to the referring physician within 12-24 hours from receipt of the specimen. Final results including electron microscopy results are typically reported within three to four days from receipt of the specimen. Nephrologists have direct cell phone access to the on call Renal Pathologist. For stat requests, (same day and weekend review as clinically indicated), please clearly state who to call on the requisition sheet.

 Dense intramembranous disease C3 (immunofluorescence)
 Dense intramembranous disease C3 (immunofluorescence)

Renal Pathology requisition form

Our services include:

  1. Wet tissue analysis
    • We supply fixative/solution filled specimen containers for light microscopy, immunofluorescence and electron microscopy.  Please call 650-725-5196 to request kidney biopsy kits.  Daily courier service is available within much of the Bay Area.  For clients not serviced by our courier routes, we provide specimen transport by FedEX.  Please call 650-723-7211 for preaddressed mailers.

  2.  Immunofluorescence and immunohistochemistry
    • We perform direct immunofluorescence on frozen tissue samples. Routine testing includes staining for C3, IgG, IgM, IgA, C1q, kappa, lambda, fibronogen and albumin..  Additional antibodies that may be applied to the tissue include serum-associated amyloid, amyloid P, transthyretin (amyloid subtyping), alpha3 and alpha5 chains of type IV collagen (Alport syndrome work up), and IgG heavy chain subclass identification (IgG1-4).  Immunohistochemical staining for polyoma virus and cytomegalovirus,
      B-and T-lymphocyte subsets, IgG4 heavy chain and C4d is performed on formalin fixed tissue sections or sections from submitted paraffin blocks or unstained paraffin sections.

  3.  Dense intramembranous disease: intramembranous linear dense deposit and subepithelial “hump”
     Dense intramembranous disease: intramembranous linear dense deposit and subepithelial “hump”
    Electron Microscopy
    • Electron microscopy is utilized to confirm and/or establish a diagnosis. 
    • Results are typically available within five days from receipt of the specimen.

  4. Billing Information
    • When complete demographic & insurance information accompanies a specimen, we will routinely direct our billing to the client or designated third party payor. Our physician group is contracted with most of the large insurers & Medicare & Medi-Cal (in state only). If the patient has HMO coverage, we ask that an authorization for our services accompany the specimen. Billing for the professional component services occurs separately from the technical (i.e., facility) component services so a patient may receive two different statements when a copayment/deductible is involved. Client billing is available as well. If you need additional information regarding the billing processes, please contact our administrative manager, Leigh Stacy, at 650-498-7840.


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